R peptides

R peptides DEFAULT

Peptides Build Status CRAN_Download_Badge

aaListReturn a vector with the 20 standard aminoacids in upper caseaaCompCompute the amino-acid composition of a protein sequenceaaDescriptorsCompute 66 descriptors for each amino acid of a protein sequenceaIndexCompute the aliphatic index of a protein sequenceautoCorrelationCompute the auto-correlation index of a protein sequenceautoCovarianceCompute the auto-covariance index of a protein sequenceblosumIndicesCompute the BLOSUM62 derived indices of a protein sequencebomanCompute the Boman (Potential Protein Interaction) indexchargeCompute the theoretical net charge of a protein sequencecrossCovarianceCompute the cross-covariance index of a protein sequencecrucianiPropertiesCompute the Cruciani properties of a protein sequencefasgaiVectorsCompute the FASGAI vectors of a protein sequencehmomentCompute the hydrophobic moment of a protein sequencehydrophobicityCompute the hydrophobicity index of a protein sequenceinstaIndexCompute the instability index of a protein sequencekideraFactorsCompute the Kidera factors of a protein sequencelengthpepCompute the aminoacid length of a protein sequencemassShiftCompute the mass difference of a protein sequence labelled with stable isotope.membposCompute theoretically the class of a protein sequencemswhimScoresCompute the MS-WHIM scores of a protein sequencemwCompute the molecular weight of a protein sequencemzCompute the mass over charge (m/z) of a protein sequencepICompute the isoelectic point (pI) of a protein sequenceplotXVGPlot time series from GROMACS XVG filesprotFPCompute the protFP descriptors of a protein sequencereadXVGRead XVG files from GROMACS molecular dynamics packagestScalesCompute the ST-scales of a protein sequencetScalesCompute the T-scales of a protein sequencevhseScalesCompute the VHSE-scales of a protein sequencezScalesCompute the Z-scales of a protein sequence
Sours: https://github.com/dosorio/Peptides

Identification of R-peptides in envelope proteins of C-type retroviruses

Activation of the murine leukaemia virus (MLV) envelope protein (Env) requires proteolytic cleavage of the R-peptide, a 16 amino acid C-terminal part of the cytoplasmic tail (C-tail) of Env. This paper demonstrates the presence of R-peptides in Env proteins of C-type retroviruses of simian, avian and porcine origin. Sequence alignment with the MLV C-tail led to the identification of a conserved hydrophobic protease cleavage motif located in the centre of retroviral Env protein C-tails. Expression of Env proteins, truncated at the predicted cleavage sites, of spleen necrosis virus (SNV), gibbon ape leukaemia virus and porcine endogenous retroviruses resulted in cell-cell fusion as monitored by microscopy and reporter gene fusion assays. Western blot analysis of MLV particles pseudotyped with the SNV Env protein demonstrated proteolytic cleavage of the SNV R-peptide by the MLV protease. Our data suggest that activation of membrane fusion by R-peptide cleavage is a common mode in C-type retroviruses.

Sours: https://pubmed.ncbi.nlm.nih.gov/12185279/
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3.02.21 — Genetic Engineering & Biotechnology News: Treating Parkinson’s Disease with Individualized Brain Cell Grafts | Synucleins

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8.25.20 — Science Daily: Study leads to potential for new treatment approach for Alzheimer's | Beta Amyloids

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8.19.20 — Michigan Medicine: Potential New Blood Test in Alzheimer’s Disease Could Advance Treatment | Beta Amyloids

8.14.20 — Science Times: The Importance of Blood Tests for Alzheimer's Disease Patients: 2 Neuroscientists Explain... | Tau Proteins

8.06.20 — Parkinson's News Today: Researchers, Advocates Collaborate for In-depth Review of Clinical Trials Targeting... | Synucleins

8.03.20 — EurekAlert: New study on development of Parkinson's disease is 'on the nose' | Synucleins

7.29.20 — New Scientist: Boosting gut microbes helps protect mice against Alzheimer’s disease | Beta Amyloids

7.28.20 — Medical Xpress: Study reveals how renegade protein interrupts brain cell function in Alzheimer's disease | Tau Proteins

7.24.20 — Medical Xpress: Novel drug delivery particles use neurotransmitters as a 'passport' into the brain | Tau Proteins

7.22.20 — Medical Xpress: What happens around an Alzheimer plaque? | Beta Amyloids

7.15.20 — Neuroscience News: Super-Agers Show Resistance to Tau and Amyloid Accumulation | Tau Proteins

7.14.20 — Parkinson's News Today: Salmonella Can Form Biofilms, May Be Tied to Disease via Autoimmune Reaction | Synucleins

7.14.20 — Being Patient: Five Reason The Coronavirus Pandemic Has Caused a Surge in Alzheimer’s Deaths | Beta Amyloids

7.08.20 — Neuroscience News: Delirium, Rare Brain Inflammation and Stroke Linked to Covid-19 | Beta Amyloids

7.06.20 — Medical News Bulletin: Is there a link between gut microbiome and Parkinson’s disease? | Synucleins

6.29.20 — Genetic Engineering & Biotechnology News: Atomic Structure of Alzheimer’s Amyloid Protein Reveals... | Beta Amyloids

6.25.20 — Technology Networks: More Severe Alzheimer's Subtype May Be Caused by Tau Modifications | Tau Proteins

6.23.20 — Parkinson's News Today: Perturbations in the Body’s Internal Clock Linked to Greater Risk of Parkinson’s,... | Synucleins

6.22.20 — UC Davis: UC Davis Researchers Adapt Amyloid Technology to Catch Coronavirus | Beta Amyloids

6.18.20 — Parkinson's News Today: Changes in Structure of Alpha-synuclein Seen to Make Protein Prone to Clumping | Synucleins

6.18.20 — EurekAlert: The Parkinson's disease gut has an overabundance of opportunistic pathogens | Synucleins

6.15.20 — MIT News: Study finds path for addressing Alzheimer’s blood-brain barrier impairment | Beta Amyloids

6.11.20 — EurekAlert: Solving a Parkinson's disease puzzle through protein design | Synucleins

6.08.20 — News Medical Life Sciences: Using antibodies to detect Alzheimer’s disease | Beta Amyloids

6.04.20 — EurekaAlert!: Insight into protein misfolding could open up new approaches to treat Parkinson's disease | Synucleins

6.03.20 — Harvard Health Publishing: In search of sleep | Beta Amyloids

6.01.20 — HealthCareBusinessNews: FDA approves first PET tracer for tau Alzheimer's imaging | Tau Proteins

5.27.20 — Gilmore Health News: Alzheimer’s Breakthrough: An Antibody That Can Recognize the Disease Much Earlier... | Beta Amyloids

5.26.20 — Genetic Engineering & Biotechnology News: Alzheimer’s Oligomeric “Seeds” Recognized by New Antibody | Beta Amyloids

5.25.20 — Newswire: Scientists Now Find Poor Sleep Is Linked With Alzheimer’s | Beta Amyloids

5.24.20 — Mental Daily: How Air Pollution May Contribute To The Onset Of Parkinson’s Disease | Synucleins

5.22.20 — Being Patient: What Are Alzheimer’s Biomarkers, and Why Should We Care About Ube2h? | Beta Amyloids

5.22.20 — Alzforum: Widely Used Tau Seeding Assay Challenged | Tau Proteins

5.21.20 — Science Daily: Scientists find evidence of link between diesel exhaust, risk of Parkinson's | Synucleins

5.19.20 — Science Daily: Protein shapes matter in Alzheimer's research | Beta Amyloids

5.18.20 — Nature Middle East: Parkinson’s pathology starts small | Synucleins

5.15.20 — University of Melbourne: Blood test to diagnose Alzheimer’s disease for Australian patients | Tau Proteins

5.13.20 — BioSpace: Novel Treatment Using Patient's Own Cells Opens New Possibilities to Treat Parkinson's Disease | Synucleins

5.12.20 — Medical Xpress: Protein shapes matter in Alzheimer's research | Beta Amyloids

5.11.20 — Asian Scientist: CRISPR Helps Find Alzheimer’s-Linked Protein | Beta Amyloids

5.07.20 — U. OF I. NEWS BUREAU: Molecule reduces multiple pathologies associated with Alzheimer’s disease | Tau Proteins

5.03.20 — Neuroscience News & Research: APOE4, a Genetic Culprit for Alzheimer’s Disease, Triggers Leaks in... | Beta Amyloids

5.01.20 — News Medical Life Sciences: Identifying Early Symptoms in Parkinson’s | Synucleins

4.27.20 — EurekAlert: Reducing early brain inflammation could slow Alzheimer's progression | Beta Amyloids

4.22.20 — EurekAlert: New blood test for Alzheimer's developed | Tau Proteins

4.17.20 — Being Patient: New Genetic Variant Discovered to Protect Against Risk of Alzheimer’s Gene ApoE4 | Beta Amyloids

4.16.20 — Being Patient: Largest Alzheimer’s Study on Protein Networks Reveals Possible New Biomarker | Beta Amyloids

4.12.20 — Health24: Young-onset Parkinson's may start in the womb | Synucleins


4.07.20 — EurekAlert: New method to monitor Alzheimer's proteins | Beta Amyloids

4.06.20 — Science Daily: Alzheimer's trial screening data links high amyloid levels with early stage disease | Beta Amyloids

4.02.20 — Being Patient: Researchers Pinpoint New Alzheimer’s Biomarker in Blood | Beta Amyloids

3.31.20 — Parkinson'sNewsToday: ‘Microstretcher’ Technique May Advance Parkinson’s Research | Synucleins

3.25.20 — Parkinson'sNewsToday: Study to Test MRI Technique for Possible Early Parkinson’s Diagnosis | Synucleins

3.24.20 — Parkinson's News Today: APOE Variant Directly Tied to Lewy Body Dementias in 2 Studies | Synucleins

3.20.20 — Being Patient: Lack of Sleep Could Hurt The Brain’s Ability To Clear Out Toxins | Beta Amyloids

3.15.20 — News Medical Life Sciences: Alzheimer's and its helper protein | Tau Proteins

3.12.20 — PhysOrg: Gold nanoparticles uncover amyloid fibrils | Beta Amyloids

3.02.20 — NEUROLOGICAL HEALTH: Tau Shows Promise as Achilles’ Heel for Alzheimer’s and Similar Diseases | Tau Proteins

3.02.20 — Scientific American: Tau Shows Promise as Achilles’ Heel for Alzheimer’s and Similar Diseases | Tau Proteins

3.01.20 — Medical News Bulletin: How do cells regulate proteins that are on the outside of their membranes? | Beta Amyloids

2.26.20 — Medical News Today: Scientists find new way to save neurons in Alzheimer’s disease | Beta Amyloids

2.25.20 — Alzheimer's News Today: New Carbon Nanotube Sensor Ably Spots Alzheimer’s via Proteins in Blood,... | Beta Amyloids

2.24.20 — Parkinson'sNewsToday: Study Shows Age-dependent Spread Of Alpha-synuclein From Gut to Brain in Mice | Synucleins

2.19.20 — HelioPsychiatry: Combined testing may detect Alzheimer's disease | Beta Amyloids

2.17.20 — Parkinson'sNewsToday: Light-activated Protein Used to Improve Mitochondrial Function, Reduce Parkinson’s... | Synucleins

2.11.20 — Being Patient: New Blood Test Detects Alzheimer’s Biomarkers in Plasma | Beta Amyloids


1.28.20 — Medical News Today: Parkinson’s: New treatment targets two nerve systems at once | Synucleins

1.22.20 — The Science Advisory Board: Small-molecule chaperones may reverse Alzheimer's symptoms in mice | Beta Amyloids

1.20.20 — Parkinson'sNewsToday: Deleting Specific Region of Alpha-Synuclein Protein May Prevent Parkinson’s Symptoms,... | Synucleins

1.14.20 — FierceBiotech: Gut link to Parkinson's sparks talk of probiotic treatment strategy | Synucleins

1.10.20 — Alzheimer's News Today: New Clues on CD33 Protein’s Role in Alzheimer’s May Be Key to Treatment,... | Beta Amyloids

1.06.20 — HealthITAnalytics: Alzheimer’s Tau Protein Could Advance Cognitive Precision Medicine | Tau Proteins

1.05.20 — PsychCentral: Tau Protein Tangles May Predict Sites of Brain Degeneration in Alzheimer’s | Tau Proteins

1.01.20 — Being Patient: Tau Protein Drives Alzheimer’s More Than Beta-Amyloid, Study Says | Tau Proteins

12.27.19 — Asian Scientist: Metabolic Defects Precede Alzheimer’s Disease, Study Finds | Beta Amyloids

12.24.19 — Medscape: Mixed Results With Leukemia Drug in Parkinson's | Synucleins

12.24.19 — NewsMax: Alzheimer's Blood Test Carries Moral Dilemma | Beta Amyloids

12.16.19 — Medical Xpress: Study examines HIV drug's potential to treat Alzheimer's | Beta Amyloids

12.10.19 — The Herald: Protein may be key in treatment of dementia, say Scots scientists | Tau Proteins

12.05.19 — Free Press Journal: Brain blood vessel combats Alzheimer’s disease | Beta Amyloids

12.02.19 — Parkinson's News Today: Iron Accumulation in Brain Detected With High-Resolution MRI Technique, Animal Study... | Synucleins

11.25.19 — The Cure Parkinson's Trust: Genetic Manipulators of Alpha Synuclein | Synucleins

11.22.19 — Medical News Today: Inflammation drives tau damage in Alzheimer's | Tau Proteins

11.20.19 — News Medical Life Sciences: Inflammatory processes drive progression of neurodegenerative brain diseases | Tau Proteins

11.15.19 — News Medical Life Sciences: Researchers evaluate potential of FMT, pre- and probiotics to treat Parkinson's... | Synucleins

11.13.19 — EurekaAlert!: Targeting alpha-synuclein in the gut may slow down Parkinson's disease | Synucleins

11.08.19 — Medical Xpress: Study finds key Alzheimer's gene (APOE) acts differently in Caribbean Hispanics | Beta Amyloids

11.04.19 — STAT: She was destined to get early Alzheimer’s, but didn’t. Did a rare mutation protect her? | Beta Amyloids

10.30.19 — CNN Health: Lifestyle changes improved cognition in people at risk for Alzheimers, study shows | Beta Amyloids

10.25.19 — Medscape: Visual Dysfunction: An Underrecognized Symptom of Parkinson's? | Synucleins

10.21.19 — Parkinson's News Today: Scientists Develop New Compound That Could Potentially Slow Parkinson’s Progression | Synucleins

10.15.19 — Science Daily: Changes associated with Alzheimer's disease detectable in blood samples | Beta Amyloids

10.09.19 — Northern Star: Sleep deprivation could have scary consequences | Beta Amyloids

9.25.19 — Genetic Literacy Project: Experimental blood tests for Alzheimer’s could boost research, treatment... | Beta Amyloids

9.11.19 — Parkinson's News Today: Lewy Bodies Diverse in Structure and Some Fibrils Can Migrate, Study Reports | Synucleins

9.03.19 — Science Daily: The seeds of parkinson's disease: Amyloid fibrils that move through brain | Synucleins

8.29.19 — Medical Xpress: Does a prion hypothesis explain Parkinson's? The jury is still out | Synucleins

8.23.19 — Being Patient: https://www.beingpatient.com/researchers-pinpoint-alzheimers-gene-linked-to-rare-neurological-disorder/ | Beta Amyloids

8.20.19 — Medical News Today: Spontaneous chemistry' may drive Alzheimer's | Beta Amyloids

8.12.19 — Tech Explorist: Alzheimer’s disease destroys neurons that keep us awake | Tau Proteins

8.08.19 — Neurology Today: Elevated Plasma Tau Predicts Stroke Risk Over and Above Other Factors | Tau Proteins

8.04.19 — New Atlas: Alzheimer’s blood test could replace PET brain scans after hitting 94 percent accuracy | Beta Amyloids

7.22.19 — Everyday Health: Blood Biomarkers Show Promise for Identifying Alzheimer’s Disease | Beta Amyloids

6.26.19 — The Guardian: Growing evidence suggests Parkinson's disease starts in gut | Synucleins

6.26.19 — Managed Care: Stat: Beta-amyloid 'cabal' has stymied progress on Alzheimer's | Beta Amyloids

6.25.19 — Neurology Advisor: Cognitive Decline Associated With Successive Amyloid-Beta and Tau Changes | Tau Proteins

6.24.19 — Science Daily: Alzheimer's missing link ID'd, answering what tips brain's decline | Beta Amyloids

6.24.19 — Parkinson's News Today: Brain Serotonin Changes May Be Early Warning Sign of Parkinson’s, Study Suggests | Synucleins

6.14.19 — BioSpace: Research Roundup: A New Protein Linked to Alzheimer’s and Other Highlights | Beta Amyloids

6.11.19 — Genetic Engineering & Biotechnology News: Natural Anti-Parkinson’s Mechanism Discovered That Targets Fibrils,... | Synucleins

6.06.19 — NNR: Alpha-synuclein Mouse Study Stops Parkinson's Before it Can Begin | Synucleins

6.03.19 — Jama Neurol: Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease | Tau Proteins

5.29.19 — Being Patient: Herpes Accelerates the Development of Alzheimer’s, Finds New Study | Beta Amyloids

5.29.19 — Parkinson's News Today: Alpha-synuclein in Blood Serum May Be Early Parkinson’s Biomarker, Study Suggests | Synucleins

5.21.19 — Phys Org: Amyloid fibrils lit with near-infrared radiation found to emit a dim, near-infrared signal | Beta Amyloids

5.20.19 — PhysicsWorld: Imaging techniques shed light on amyloid fibrils associated with Alzheimer’s disease | Beta Amyloids

5.10.19 — Alzforum: Forget Fibrils: Lewy Pathology Is More Lipid Than Protein | Synucleins

5.07.19 — Science News: Alzheimer’s Amyloid-Beta and Tau Proteins Act as Prions, New Research Finds | Tau Proteins

5.07.19 — EurekaAlert!: Novel and rapid device opens new doors for Parkinson's disease diagnostics | Synucleins

4.30.19 — Newsweek: Poor Sleep Tied to Increase in Alzheimer's-linked Protein Tau | Tau Proteins

4.15.19 — Being Patient: New Study Shows How Tau Spreads Across the Brain in Alzheimer’s | Tau Proteins

2.27.19 — Hypertension: Alpha-synuclein deposition within sympathetic noradrenergic neurons is associated with myocardial... | Synucleins

2.27.19 — Discover: Missing Out On Deep Sleep Causes Alzheimer’s Plaques to Build Up | Beta Amyloids

2.22.19 — Alzforum: Viral Vectors Trigger Robust Tauopathy in Brain Slices | Tau Proteins

2.22.19 — The American Journal of Geriatric Psychiatry: Increased Serum Levels of ?-Synuclein in Patients With Major... | Synucleins

2.21.19 — UPI: Alzheimer's breakthrough may come from bone marrow experiment with mice | Beta Amyloids

2.20.19 — Boston University School of Medicine: 75,000-molecule Screen Reveals Amyloid-reducing | Beta Amyloids

2.20.19 — Neurology Today: Parkinson's Disease Mutation May Trigger Astrocyte-Driven Neural Alpha-Synucleinopathy | Synucleins

2.19.19 — EurekaAlert!: Possible pathway to new therapy for Alzheimer's disease | Beta Amyloids

2.19.19 — Sleep Review: Supine Sleep Linked to Neurodegenerative Disease | Tau Proteins

2.17.19 — Observer-Reporter: As research continues, Alzheimer's remains mysterious disease | Beta Amyloids

2.15.19 — Science Magazine: Recognition of the amyloid precursor protein by human ?-secretase | Beta Amyloids

2.15.19 — EurekaAlert!: Brain discovery explains a great mystery of Alzheimer's, Parkinson's | Beta Amyloids

2.12.19 — Sciworthy: Parkinson’s disease and your appendix | Synucleins

2.12.19 — National Institute on Aging: Sleep loss encourages spread of toxic Alzheimer’s protein | Beta Amyloids

2.11.19 — News Medical Life Sciences: Alzheimer's disease protection from exercise hormone irisin | Beta Amyloids

2.08.19 — Fierce Biotech: How a decades-old HIV drug might help treat Alzheimer's, age-related diseases | Beta Amyloids

2.08.19 — Alzforum: Clotting Protein from Blood Incites Microglia, and Synapses Die | Beta Amyloids

2.07.19 — Science Daily: The involvement of the gut in Parkinson's disease: hype or hope? | Synucleins

2.06.19 — University of Manchester: A Map to the Alzheimer's Brain | Beta Amyloids

2.06.19 — Discover: Women’s Brains Are Younger Than Men’s of the Same Age, Study Finds | Beta Amyloids

2.06.19 — EurekaAlert!: Voluntary control of brainwaves in deep brain of patients with Parkinson's disease | Synucleins

2.05.19 — Science Trends: Who Knew What Tau In Oligodendrocytes Can Do? | Tau Proteins

2.01.19 — Scientific America: Better Biomarkers Could Help Us Treat Alzheimer’s | Beta Amyloids

1.31.19 — Parkinson's News Today: Cellular Location of Neuroprotective Protein Associated with Parkinson’s Disease... | Synucleins

1.31.19 — Parkinson's News Today: Cellular Location of Neuroprotective Protein Associated with Parkinson’s Disease... | Synucleins

1.29.19 — Medical Pres: Researchers use AI to detect early signs of Alzheimer's | Beta Amyloids

1.26.19 — Insider: Alzheimer's could be caused by bad oral hygiene, according to new research — further evidence... | Beta Amyloids

1.24.19 — Washington University School of Medicine in St.: Sleep deprivation accelerates Alzheimer’s brain... | Tau Proteins

1.19.19 — Alzforum: nvasion of the Microtubules: Mutant Tau Deforms Neuronal Nuclei | Tau Proteins

1.18.19 — EurekaAlert!: How gut bacteria affect the treatment of Parkinson's disease | Synucleins

1.18.19 — Fortune: Could This Radical New Approach to Alzheimer’s Lead to a Breakthrough? | Beta Amyloids

1.16.19 — Medical News Today: Experimental drug may prevent Alzheimer's disease | Beta Amyloids

1.15.19 — Science Daily: Defective glial cells can push neurons toward Parkinson's disease | Synucleins

1.14.19 — News Medical Life Sciences: The Tau (CDK5) Signaling Pathway | Tau Proteins

1.12.19 — Alzforum: Tau, More than A?, Affects Sleep Early in Alzheimer’s | Tau Proteins

1.11.19 — Parkinson's News Today: Abnormal Brain Cell Type Leads to Parkinson’s-Related Neurodegeneration, Study Contends | Synucleins

1.10.19 — Medical New Today: Alzheimer's: 9 new genetic risk factors found | Beta Amyloids

1.10.19 — News Medical Life Sciences: Defective astrocytes linked to alpha-synuclein accumulation in Parkinson's | Synucleins

1.09.19 — Everyday Health: Study Links Decreased Deep Sleep to Early Signs of Alzheimer’s Disease | Beta Amyloids

1.07.19 — Everyday Health: Study Reveals Racial Differences in Alzheimer’s Disease | Beta Amyloids

1.03.19 — Futurity: Drinkable ‘cocktail’ stymies Alzheimer’s disease at its start | Beta Amyloids

1.03.19 — Parkinson's News Today: Researchers, Michael J. Fox Foundation Propose New Roadmap for Trials | Synucleins

1.02.19 — Parkinson's News Today: Top 10 Parkinson’s Stories of 2018 | Synucleins

1.02.19 — Daily Mail.com: Could 'young blood' cure Parkinson's disease? Scientists are giving transfusions that may... | Synucleins

12.31.18 — The Telegraph: Injection to halt the progress of Alzheimer’s 'available within decade' | Beta Amyloids

12.30.18 — New Hampshire Union Leader: Reviewing all published Alzheimer's research could yield game-changing... | Beta Amyloids

12.30.18 — MEDPAGE Today: Is the Rising Storm of Alzheimer's Disease Stoppable? | Beta Amyloids

12.30.18 — Enid News & Eagle: Parkinson's: With work, there is hope after the diagnosis | Synucleins

12.26.18 — Pharmaceutical Technology: The industry shift to anti-tau therapies to treat Alzheimer’s | Tau Proteins

12.20.18 — Journal of Parkinspn's Disease: Parkinson’s Disease Experts Devise a Roadmap for Developing Drugs Targeting... | Synucleins

12.17.18 — Edmonton Journal: Research opens up possibility of saliva test for Alzheimer's disease | Beta Amyloids

12.05.18 — EMBO Press: Tau protein liquid–liquid phase separation can initiate tau aggregation | Tau Proteins

8.06.18 — www.drugtargetreview.com: pH imbalance in astrocytes may lead to Alzheimer’s disease | Beta Amyloids

8.02.18 — https://www.sciencedaily.com: Newly characterized molecule offers possibilities for novel Alzheimer's... | Beta Amyloids

8.01.18 — https://www.mdlinx.com: More potent Alzheimer's therapy is on its way | Beta Amyloids

7.28.18 — https://www.medicalnewstoday.com: Parkinson's gene affects more people than previously thought | Beta Amyloids

7.26.18 — https://www.news-medical.net: Parkinson's therapies being developed may benefit everybody with the... | Beta Amyloids

7.25.18 — https://www.forbes.com: Evidence Mounts That Germs May Cause Alzheimer's | Beta Amyloids

7.20.18 — http://www.jbc.org: The effect of truncation on prion-like properties of ?-synuclein | Synucleins

7.17.18 — https://www.cnn.com: Bill Gates jump-starts research for an affordable Alzheimer's test | Beta Amyloids

7.16.18 — https://phys.org: The secret sulfate code that lets the bad Tau in | Tau Proteins

7.12.18 — http://www.abc.net.au: Does methamphetamine use increase your risk of developing Parkinson's disease? | Beta Amyloids

7.10.18 — http://www.pharmatimes.com: The dementia dilemma | Beta Amyloids

7.05.18 — https://www.sciencedaily.com: Rethinking neurodegenerative disease treatment: Target multiple pathological... | Synucleins

7.03.18 — https://www.newsweek.com: Alzheimer’s Could One Day Be Treated With Common Drug, Study in Mice Suggests | Beta Amyloids

7.02.18 — https://alzheimersnewstoday.com: https://alzheimersnewstoday.com/2018/06/29/alcohol-seen-to-hinder-brains-ability-to-clear-protein-linked-to-alzheimers-disease/ | Beta Amyloids

6.28.18 — https://www.biorxiv.org: Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent... | Synucleins

6.27.18 — https://healthblog.uofmhealth.org: Family Connection Motivates Alzheimer’s Research | Beta Amyloids

6.25.18 — https://www.dovepress.com: Senkyunolide A protects neural cells against corticosterone-induced apoptosis... | Beta Amyloids

6.20.18 — http://www.xinhuanet.com: Stem cell therapy may help cure Parkinson's disease: research | Tau Proteins

6.20.18 — https://parkinsonsnewstoday.com: Cerium Oxide Nanoparticles Hold Therapeutic Potential for Parkinson’s,... | Beta Amyloids

6.18.18 — https://www.biorxiv.org: C. elegans genetic background modifies the core transcriptional response in an ?-synuclein... | Synucleins

6.17.18 — https://sivtimes.com: Scientists have discovered the mechanism of development of Parkinson’s disease | Synucleins

6.16.18 — https://parkinsonsnewstoday.com: Accumulated Alpha-Synuclein in Retina Could Measure Parkinson’s Severity,... | Synucleins

6.15.18 — https://medicalxpress.com: Scientists unravel molecular mechanisms of Parkinson's disease | Synucleins

6.15.18 — https://www.alzforum.org: In Human Neurons, ApoE4 Promotes A? Production and Tau Phosphorylation | Tau Proteins

6.13.18 — https://reliawire.com: Key Parkinson’s Biomarker Can Be Detected In The Retina | Synucleins

6.13.18 — https://www.pharmiweb.com: Better Sleep Can Prevent Cognitive Decline | Beta Amyloids

5.30.18 — https://phys.org: Simulations show how beta-amyloid may kill neural cells | Beta Amyloids

5.30.18 — http://www.cardiovascularbusiness.com: Combo of vascular risk, brain amyloid could quicken mental... | Beta Amyloids

5.30.18 — https://scicasts.com: Tau Mutations may Increase Cancer Risk, Research Finds | Tau Proteins

5.30.18 — https://www.psychologytoday.com: Mild Traumatic Brain Injury Increases Risk of Parkinson's | Synucleins

5.30.18 — http://turnto10.com: Health Check: New method of tackling Alzheimer's disease | Tau Proteins

5.30.18 — https://www.alzforum.org: At AAN, Sights Set on Antisense Therapies for Diseases of the Brain | Tau Proteins

5.30.18 — http://www.thedp.com: A new Penn study finds Parkinson's-related disorders may be dependent on cell type | Synucleins

5.30.18 — https://www.genomeweb.com: Cancer Increase Reported in Families With Tau Mutation-Associated Neurodegeneration | Tau Proteins

5.30.18 — https://www.eurekalert.org: Tau mutations may increase cancer risk | Tau Proteins

5.30.18 — http://annals.org: Amyloid-? (1-40) and Mortality in Patients With Non–ST-Segment Elevation Acute... | Beta Amyloids

5.21.18 — https://www.healththoroughfare.com: Parkinson’s Disease Diagnosis Method By Scanning Patients’ Retinas... | Synucleins

5.10.18 — https://www.sciencedaily.com: Molecule could improve memory, reduce Alzheimer's degradation, study... | Tau Proteins

5.10.18 — https://thecostaricanews.com: Cholesterol Also Increases Alzheimer’s Risk | Beta Amyloids

5.10.18 — https://www.uab.edu: Untangling brain neuron dysfunction in Parkinson’s disease and dementia with Lewy bodies | Synucleins

5.10.18 — http://healthcare.dmagazine.com: Alzheimer’s Researchers Stress The Importance of Detecting Its... | Beta Amyloids

5.10.18 — https://www.sciencedaily.com: Structural model of physiological tau-microtubule interactions sheds... | Tau Proteins

5.10.18 — https://medicalxpress.com: Untangling brain neuron dysfunction in Parkinson's disease and dementia with Lewy... | Synucleins

5.10.18 — https://www.drugtargetreview.com: Diverse Parkinson’s-related disorders may stem from different strains... | Synucleins

5.09.18 — ScienceDaily: Diverse Parkinson's-related disorders may stem from different strains of same protein | Synucleins

5.09.18 — GEN News: https://www.genengnews.com/gen-news-highlights/alzheimers-like-clumping-proteins-found-in-diseased-hearts/81255806 | Synucleins

5.07.18 — Medical Press: Brain cholesterol associated with increased risk of Alzheimer's disease | Beta Amyloids

5.04.18 — FierceBiotech: Fox Foundation and Charles Rivers renew Parkinson's research Collaboration | Synucleins

5.03.18 — Endpoints News: Merck study may signal doom for a broad group of pivotal Alzheimer’s studies | Tau Proteins

5.03.18 — Newsweek: Eating a Mediterranean Diet Could Offer Delay Alzheimer’s Disease by Years | Beta Amyloids

5.03.18 — Parkinsons News Today: Cell Study Provides Hope for Treatment of Parkinson’s Disease | Synucleins

5.03.18 — Parkinsons News Today: LRRK2 Worthy Target of Research into Parkinson’s Therapies, Study Suggests | Synucleins

5.03.18 — Daily Mail: Mediterranean diet may delay Alzheimer's disease by more than three years: Eating lots... | Beta Amyloids

5.02.18 — The Rhode Show: Advocating for Alzheimer's Awareness | Tau Proteins

5.02.18 — University of Hawaii's News: New approach to potentially stop Alzheimer’s disease discovered by... | Beta Amyloids

4.30.18 — UPI: Music may help alleviate anxiety in Alzheimer's patients | Tau Proteins

4.19.18 — SciTech Daily: Excess Levels of Calcium in Brain Cells Linked to Parkinson’s Disease | Synucleins

4.03.18 — Forbes: Aging Parents With Alzheimer's Disease: Reducing Your Own Risk | Beta Amyloids

3.26.18 — UPI: Scientists remove Alzheimer's brain plaques in mice | Beta Amyloids

3.21.18 — NY Daily News: A compound in beets could slow Alzheimer's effects | Beta Amyloids

3.21.18 — The OCR: Cal State Fullerton expert: SHIELD-ing yourself against Alzheimer’s | Beta Amyloids

3.21.18 — The Telegraph: What are the early signs of Alzheimer’s? | Tau Proteins

3.20.18 — U.S. News: Report: Alzheimer’s Disease Will Cost U.S. $277B in 2018 | Synucleins

3.16.18 — Scicasts: Cell Therapy Could Improve Brain Function For Alzheimer's Disease | Beta Amyloids

3.12.18 — CBS: Daytime Drowsiness Increases Risk Of Alzheimer’s In Elderly, Study Says | Beta Amyloids

3.12.18 — WABI: Alzheimer's study aims to prevent disease | Beta Amyloids

6.09.17 — Alzforum: Hot DAM: Specific Microglia Engulf Plaques | Beta Amyloids

3.01.17 — American Technion Society: Researchers suggest new theory for how Parkinson's disease develops | Synucleins

2.13.17 — Temple Health: More Evidence Alzheimer's is a Type of Diabetes | Tau Proteins

2.07.17 — michaeljfox.org: Linking Three Proteins to Parkinson's | Tau Proteins

12.15.15 — Runners World: Exercise May Be the Best Weapon Against Alzheimer’s | Tau Proteins

12.14.15 — BioTechin: Taurine-Like Chemical Restores Cognitive Function in Mice with Alzheimer’s | Beta Amyloids

12.14.15 — World First: New drug 'could tackle Alzheimer's plaques' | Tau Proteins

12.14.15 — MIT Technology: Are Young Athletes Risking Brain Damage? | Tau Proteins

12.14.15 — ABS News: Concussion' Doctor Changes the Conversation About High-Contact Sports | Tau Proteins

12.13.15 — Health News Florida: Alzheimer's Trial Struggles To Find Participants | Beta Amyloids

12.10.15 — News Medical: Alzheimer’s tangles and plaques: what’s the difference? | Tau Proteins

12.10.15 — Evolution News: Respect for Kinesin Grows | Tau Proteins

12.04.15 — KSat: Preventing Parkinson's: Medicine's Next Big Thing? | Synucleins

12.03.15 — Neurology Today: Does Vagotomy Reduce the Risk for Parkinson's Disease? | Synucleins

12.02.15 — Bostobn Globe: Boston is on the verge of remarkable breakthroughs for our toughest medical conditions | Tau Proteins

12.01.15 — Smithsonian: The Two Brains at the Forefront of the Fight Against Alzheimer's | Tau Proteins

12.01.15 — Helath Aim: Loss of Synapses: Initial Effects of Alzheimer’s | Tau Proteins

12.01.15 — Ledger Gazette: Alzheimer’s: Amyloid beta may contribute to lower BRCA1 Protein levels | Beta Amyloids

12.01.15 — Medical News Today: Newly evolved human gene prevents Alzheimer's | Beta Amyloids

11.30.15 — Independent: Alzheimer’s disease: Connections between brain cells destroyed in early stages of... | Beta Amyloids

11.30.15 — Daily Mail: The secret of old age revealed: 'Grandparent gene' protects the elderly from dementia... | Beta Amyloids

11.30.15 — UC San Diego Health: Newly Evolved, Uniquely Human Gene Variants Protect Older Adults from Cognitive... | Beta Amyloids

11.30.15 — Time: How a Breast Cancer Gene May Affect Alzheimer’s | Beta Amyloids

11.30.15 — San Francisco Business Times: How a failed protein could unleash a new wave of Alzheimer's research | Tau Proteins

11.24.15 — EurekAlert: Slower aging may protect cells in the brain from Parkinson's disease | Synucleins

11.23.15 — Elko Daily: Research into brain trauma reveals cell-killing protein | Tau Proteins

11.23.15 — Kera News: Lewy Body Dementia: Why A Common Disorder Is Often Misdiagnosed | Synucleins

11.18.15 — IBTimes: Blue LED lights may help treat Alzheimer's disease by suppressing beta-amyloid structure... | Beta Amyloids

11.18.15 — Alzheimers News Today: Alzheimer’s-Linked Protein Seems to Respond to Exercise | Tau Proteins

11.12.15 — Time: Concussion Hits But Doesn’t Sack the NFL | Tau Proteins

11.12.15 — Medical Xpress: Using light to treat Alzheimer's disease | Beta Amyloids

11.10.15 — Chicago Tribune: Sleep could be the missing link in dementia | Beta Amyloids

11.10.15 — Psychiatry Advisor: Hyperactive Neurons Behind Failure of Immunotherapy for Alzheimer's | Beta Amyloids

11.10.15 — CNBC: A disease on track to bankrupt Medicare | Beta Amyloids

11.09.15 — CNN Money: Anavex Announces Positive Primary and Secondary Endpoints Were Achieved in a Phase 2a Clinical... | Tau Proteins

11.09.15 — News Max: Prevent Cancer, Heart Disease With Delicious Ethnic Cuisine Read more: Prevent Cancer,... | Beta Amyloids

11.09.15 — Dark Daily: Identification of New Biomarker for Alzheimer’s Could Set Stage for Clinical Laboratory... | Tau Proteins

11.09.15 — The Sand Diego Tribune: Alzheimer's therapy impairs cognition in animals | Beta Amyloids

11.08.15 — HHMI: Deisseroth and Hobbs Awarded Breakthrough Prizes | Beta Amyloids

11.04.15 — Medical Xpress: Reducing harmful proteins in the fight against dementia | Synucleins

11.03.15 — Live Science: Robin Williams' Death: What Is Lewy Body Dementia? | Synucleins

10.29.15 — Bioscience: Study Finds How Alzheimer’s-associated Protein Tangles Spread Through the Brain | Tau Proteins

10.26.15 — Medical Xpress: Study finds how Alzheimer's-associated protein tangles spread through the brain | Tau Proteins

10.22.15 — BioPharma Dive: Biogen cutting 11% of workforce, betting big on Alzheimer's R&D | Beta Amyloids

10.22.15 — Drug Discovery & Development: N.J. Researchers Closing in on Alzheimer’s, Parkinson’s Tests | Beta Amyloids

10.22.15 — Medical Xpress: Alzheimer's disease: Plaques impair memory formation during sleep | Beta Amyloids

10.22.15 — The Scotsman: Alzheimer’s drug could be available in two years | Tau Proteins

10.22.15 — BioTechin: Fungus – is it the real ‘Dementor’ in Alzheimer’s disease? | Tau Proteins

10.21.15 — The Sacramento Bee: Football trauma expert leads UC Davis panel on long-term effects of brain injury | Tau Proteins

10.20.15 — Scientific American: Are Prions behind All Neurodegenerative Diseases? | Synucleins

10.20.15 — Medical News Today: Mechanism that 'melts' protein clumps may lead to new Parkinson's treatments | Synucleins

10.17.15 — NBC News: Cancer Drug Helps Parkinson's Patients | Synucleins

10.15.15 — http://news.yahoo.com/fungus-found-brains-raises: Fungus found in brains raises Alzheimer's questions | Beta Amyloids

10.15.15 — Malay Mail Online: Scientists identify protein key to Alzheimer’s treatment - See more at: http://www.themalaymailonline.com/features/article/scientists-identify-protein-key-to-al | Beta Amyloids

Sours: https://www.rpeptide.com/
Peptide bond formation - Macromolecules - Biology - Khan Academy

Calculate Indices and Theoretical Physicochemical Properties of Protein Sequences

R package to calculate several physicochemical properties and indices for amino-acid sequences as well as to read and plot 'XVG' output files from the 'GROMACS' molecular dynamics package


This package required R version 1.2.2 or higher. If you are using an older version of R you will be prompted to upgrade when you try to install the package.

The official release of Peptides is available on CRAN. To install from CRAN, use the following command:

If you have devtools installed, install the latest stable version this package directly from GitHub:

Available functions

aaCompCompute the amino-acid composition of a protein sequence
aaDescriptorsCompute 66 descriptors for each amino acid of a protein sequence
aIndexCompute the aliphatic index of a protein sequence
autoCorrelationCompute the auto-correlation index of a protein sequence
autoCovarianceCompute the auto-covariance index of a protein sequence
blosumIndicesCompute the BLOSUM62 derived indices of a protein sequence
bomanCompute the Boman (Potential Protein Interaction) index
chargeCompute the theoretical net charge of a protein sequence
crossCovarianceCompute the cross-covariance index of a protein sequence
crucianiPropertiesCompute the Cruciani properties of a protein sequence
fasgaiVectorsCompute the FASGAI vectors of a protein sequence
hmomentCompute the hydrophobic moment of a protein sequence
hydrophobicityCompute the hydrophobicity index of a protein sequence
instaIndexCompute the instability index of a protein sequence
kideraFactorsCompute the Kidera factors of a protein sequence
lengthpepCompute the aminoacid length of a protein sequence
membposCompute theoretically the class of a protein sequence
mswhimScoresCompute the MS-WHIM scores of a protein sequence
mwCompute the molecular weight of a protein sequence
pICompute the isoelectic point (pI) of a protein sequence
plotXVGPlot time series from GROMACS XVG files
protFPCompute the protFP descriptors of a protein sequence
readXVGRead XVG files from GROMACS molecular dynamics package
stScalesCompute the ST-scales of a protein sequence
tScalesCompute the T-scales of a protein sequence
vhseScalesCompute the VHSE-scales of a protein sequence
zScalesCompute the Z-scales of a protein sequence

Available datasets

AAdataProperties, scales and indices for the 20 naturally occurring amino acids from various sources
pepdataA data frame with 21 physicochemical properties and indices from 100 amino-acid sequences (50 antimicrobial and 50 non antimicrobial)


Osorio, D., Rondon-Villarreal, P. & Torres, R. Peptides: A package for data mining of antimicrobial peptides. The R Journal. 7(1), 4–14 (2015).

D. Osorio, P. Rondón-Villarreal and R. Torres. Peptides: Calculate indices and theoretical physicochemical properties of peptides and protein sequences., 2014. URL: http: //CRAN.R-project.org/package=Peptides. R Package Version 2.2.

Sours: https://www.r-pkg.org/pkg/Peptides

Peptides r

Our class is friendly, for 8. Years after graduation we regularly meet It turned out that a couple of years ago, at a meeting of graduates, Olya and I sat next to each other. Word for word, we talked, caught one wave, drank, danced a couple of slows and, one might say, opened themselves to each other. And this is after about 20 years of dating. After a while we already met.

How To Calculate The Isoelectric Point of Amino Acids and Zwitterions

I'm not. What do you mean "not". You just don't know how to paint. Goths and beauty are two incompatible things.

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Lenka did not like such sex at all and, being always direct, she expressed her displeasure to him. Volodya said that he'll finish smoking and continue, then he suggested: Do you want me to tie you up. Moving away from the excitement, Volodya probably realized that he could fly in.

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