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What is Clonazepam for:

This medication is an anticonvulsant, muscle relaxant, prescribed for Lennox-Gastaut syndrome, panic disorder and seizures. It decreases abnormal electrical activity in the brain.

How does Clonazepam work:

Clonazepam calms the brain.

How should Clonazepam be used:

Seizure Disorders- Adults: The initial dose should not exceed 1.5 mgday divided into three doses. It may be increased if needed. Pediatric Patients: The initial dose should be between 0.01 and 0.03 mgkgday but not to exceed 0.05 mgkgday given in two or three divided doses. Panic Disorder- Adults: The initial is 0.25 mg two times per day. It may be increased if needed. It comes as a tablet to take by mouth as directed by your physician.

Common side effects of Clonazepam :

Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you. Dry mouth. Good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. See a dentist often. Feeling tired or weak. Change in balance

What do I do if I miss a dose

Take a missed dose as soon as you think about it. - If it is close to the time for your next dose, skip the missed dose and go back to your normal time. - Do not take 2 doses at the same time or extra doses. - Do not change the dose or stop this drug. - Talk with the doctor.

What precautions should I take when taking Clonazepam :

Alert your doctor if you are pregnant or if you become pregnant while being treated with Clonazepam. Use an appropriate birth control method while being treated with Clonazepam. You may wish to discuss birth control options with your doctor. - Alert your doctor if you are breastfeeding. Do not breastfeed while being treated with Clonazepam. - Alert your doctor if you have an eye disease known as glaucoma, liver disease or myasthenia gravis.

When do I need to seek medical help

If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life. Big change in balance. Change in thinking clearly and with logic. Feeling very tired or weak. If seizures are worse or not the same after starting this drug. Any rash. Side effect or health problem is not better or you are feeling worse.

Can I take Clonazepam with other medicines:

Alert your doctor if you are taking any other medicines, especially those listed here: - gastric medicine such as cimetidine - asthma medicine such as theophylline. - antifungals or antibiotics such as doxycycline, erythromycin, itraconazole - birth control pills - other epilepsy medicines. - sleeping pills. - heart or blood pressure medicines such as verapamil. - other medicines such as buprenorphine, disulfiram. Always inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics, supplements and medicines that you buy without a prescription.

Are there any food restrictions

Avoid Alcohol

How do I store Clonazepam :

Store it at room temperature and away from light.

Pregnancy Category

Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Therapeutic Classification

Anticonvulsants, Anxiolytics , Hypnotics & Sedatives

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How Soon Will You Become Dependent on Klonopin?

Asking questions once Klonopin is prescribed is a quite normal reaction. One of them is pretty hard to answer. It sounds like “How soon will I become dependent on Klonopin?” In most cases, the risk is rather minimal as the doses are adjusted depending on numerous personal conditions and other drugs administered. Yet still, ‘some’ doesn’t stand for ‘all’.

What the Drug Does In Your Body

If you read the label, you will find out that Klonopin (Clonazepam) decreases the electrical activity of the brain that became abnormal. Yes, it actually works in your brain and eliminates the effects that deprive you of a normal life. Nevertheless, it may lead to some unwanted adverse reactions.

Researchers say that around 1 in 500 patients become suicidal. Other side effects are memory difficulties and coordination issues. It all happens right after the intake. Just imagine what a prolonged use may lead to.

In the case of Klonopin, dependence is characterized by tolerance and withdrawal. Addiction leads both to a psychological dependence as well as the physical ones. Taking the medication chronically over time you allow it developing dependence.

How Old Are You?

This is perhaps one of the key factors that help to realize how soon you will become dependent or whether you can become dependent on Klonopin at all. Well, age does matter. Here what the American Society of Addiction Medicine says: during young adulthood, as well as adolescence, the process of mutation keeps functioning. At this age the exposure to Klonopin is often referred as early, thus addition development takes place in 97 % of cases.

While you are on drugs, Klonopin (Clonazepam) interferes with the process of brain growth and its development. It leaves great risks for a severe addiction. The cases with older people are rare.

If There Are Other Addicts, Chances Are Higher Than Ever

Some experts call addition a kind of a personal disease, social or even genetic. Instead of wondering how long it will take to become dependent on Klonopin, take a closer look at your family and friends. If they have the same or similar issues with any medications, then you will have them, too. It is already proven that genetic factors account for 40-60 % of one’s vulnerability to addiction.

Addiction Progression

Much depends on the dosage and duration of the treatment course. It takes time to develop a rather severe addiction. Even if you are careful enough to take the recommended dose and not more, dependency may progress. If you take pills to a prescription, dependency develops within a few months.

Abusers develop both psychological and physical addiction within weeks as their bodies build a tolerance to active ingredients. And it is obvious, the longer the term of use is, the more dependent you become.

There are users, who choose to crush pills and snort the powder in afterward. This way the drug enters the bloodstream much faster and the effect is multiplied. It’s perhaps the fastest way to develop tolerance.

People Become Dependent on Purpose

It is a real shock for many researchers. Some individuals choose to build tolerance for Klonopin just because they want to achieve the original effects. Others use it illegally as their aim is to increase the effect of some other meds and substances (like alcohol, for instance). There are those who need the ‘high’ feeling from the drug (intoxication). Another category of abusers suppresses pain with the med’s assistance.

While some people use Klonopin to bring their life back to norm, others start abusing it and killing themselves. Reading the key points once again will surely help you realize which category you want to belong to.

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Apo Clonazepam 

Indication

Clonazepam belongs to the class of medications called benzodiazepines. In general, benzodiazepines are used as a sedative or to decrease seizures or anxiety. Clonazepam is used to treat seizure disorders. It helps by slowing the activity of the nerves in the brain (i.e., the central nervous system).

Apo Clonazepam may be available under multiple brand names and/or in several different forms. Any specific brand name of Apo Clonazepam may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Apo Clonazepam may not be used for all of the conditions discussed here.

Your doctor may have suggested Apo Clonazepam for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Apo Clonazepam, speak to your doctor. Do not stop taking Apo Clonazepam without consulting your doctor.

Do not give Apo Clonazepam to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Apo Clonazepam if their doctor has not prescribed it.

Apo Clonazepam 

Dosage

The dose of clonazepam is determined based on how much is needed to control seizures and varies from person to person. It is important that the dose be individualized to your specific needs to avoid decreased coordination or excessive drowsiness.

The recommended adult starting dose of clonazepam should not be greater than 1.5 mg per day in 3 divided doses. This helps to minimize drowsiness and other side effects. Your doctor will gradually increase the dose until your seizures are controlled. The recommended maintenance dose for adults is 8 mg to 10 mg per day in 3 divided doses.

For children up to 10 years old or who weigh 30 kilograms or less, the dose is based on body weight. The starting dose should be calculated as 0.01 mg per kilogram of body weight per day to 0.03 mg per kilogram of body weight per day, divided into 2 or 3 doses. The maximum starting dose should be no more than 0.05 mg per kilogram of body weight per day. The doctor will gradually increase the dose until the child’s seizures are controlled. Generally, the maintenance dose is between 0.1 mg per kilogram and 0.2 mg per kilogram of body weight.

Clonazepam may be taken with food or on an empty stomach. Avoid drinking grapefruit juice while you are taking Apo Clonazepam as it can increase the levels of clonazepam in your blood.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Apo Clonazepam exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Apo Clonazepam at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Apo Clonazepam 

Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Apo Clonazepam. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking Apo Clonazepam. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • clumsiness or unsteadiness
  • delayed reaction
  • dizziness or lightheadedness
  • drowsiness
  • increased watering of the mouth
  • muscle weakness
  • unusual tiredness or weakness

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • abnormal thinking (disorientation, delusions, or loss of sense of reality)
  • anxiety
  • behaviour changes (e.g., aggressiveness, agitation, unusual excitement, nervousness, or irritability)
  • confusion
  • convulsions (seizures)
  • cough
  • hallucinations (hearing or seeing things that aren't there)
  • increased falls
  • memory loss of recent events
  • nightmares or trouble sleeping
  • signs of Depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)

Stop taking the medication and seek immediate medical attention if any of the following occur:

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Apo Clonazepam.

Apo Clonazepam 

Available form

0.5 mg
Each round, orange, flat-faced, bevelled-edged, compressed tablet, scored, and engraved "APO" over "C-0.5" on one side, contains 0.5 mg of clonazepam. Nonmedicinal ingredients: croscarmellose sodium, D&C Yellow No. 10 Aluminum Lake, FD&C Yellow No. 6 Aluminum Lake, lactose, magnesium stearate, microcrystalline cellulose, and polyethylene glycol.

2 mg
Each round, white, flat-faced, bevelled-edged, compressed tablet, scored and engraved "APO" over "C-2" on one side, other side plain, contains 2 mg of clonazepam. Nonmedicinal ingredients: croscarmellose sodium, lactose, magnesium stearate, microcrystalline cellulose, and polyethylene glycol.

Apo Clonazepam 

Contraindications

Do not use clonazepam if you:

Clonazepam may be used by people with open angle glaucoma who are receiving appropriate treatment.

Apo Clonazepam 

Precautions

There may be an interaction between clonazepam and any of the following:

  • Abiraterone acetate
  • alcohol
  • antihistamines (e.g,. cetirizine, doxylamine, Diphenhydramine, Hydroxyzine, Loratadine)
  • antipsychotics (e.g., Chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine, Risperidone)
  • Aprepitant
  • azelastine
  • "azole" antifungals (e.g., itraconazole, ketoconazole, Voriconazole)
  • barbiturates (e.g., butalbital, Phenobarbital)
  • benzodiazepines (e.g., Alprazolam, diazepam, lorazepam)
  • Bicalutamide
  • boceprevir
  • Bosentan
  • brimonidine
  • Buspirone
  • calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
  • chloral hydrate
  • Clonidine
  • Cobicistat
  • conivaptan
  • Crizotinib
  • Dabrafenib
  • Dasatinib
  • Deferasirox
  • Dronedarone
  • efavirenz
  • Entacapone
  • Enzalutamide
  • general anesthetics (medications used to put people to sleep before surgery) grapefruit juice
  • HIV non-nucleoside reverse transcriptase inhibitors (e.g., delavirdine, efavirenz, etravirine, nevirapine)
  • HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
  • imatinib
  • kava kava
  • macrolide antibiotics (e.g., clarithromycin, erythromycin)
  • magnesium sulfate
  • Methadone
  • mifepristone
  • Mirtazapine
  • Mitotane
  • Modafinil
  • muscle relaxants (e.g., Baclofen,  Cyclobenzaprine, methocarbamol, orphenadrine)
  • narcotic-containing medications (e.g., codeine, Oxycodone, morphine)
  • Nabilone
  • nefazodone
  • Norfloxacin
  • Olopatadine
  • Pramipexole
  • proton pump inhibitors (e.g., Lansoprazole, Omeprazole)
  • rifabutin
  • rifampin
  • Ropinirole
  • St. John's wort
  • scopolamine
  • seizure medications (e.g., Clobazam, Carbamazepine, Levetiracetam, phenobarbital, Phenytoin, primidone, Topiramate, Valproic acid, zonisamide)
  • selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Duloxetine, Fluoxetine, Paroxetine, Sertraline)
  • siltuximab
  • simeprevir
  • Tapentadol
  • tetrahydrocannabinol
  • thalidomide
  • theophyllines (e.g., Aminophylline, Oxtriphylline, Theophylline)
  • Tocilizumab
  • tolcapone
  • Tramadol
  • tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, Desipramine, Trimipramine)
  • valerian
  • Zolpidem
  • Zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Apo Clonazepam. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, the Nicotine from cigarettes, or street drugs can affect the action of many medications; you should let your prescriber know if you use them.

Apo Clonazepam 

Warnings

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take Apo Clonazepam.

HEALTH CANADA ADVISORY

October 30, 2020

Health Canada has issued new restrictions concerning the use of benzodiazepines and benzodiazepine-like prescription drugs. To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.

Alcohol: People taking Apo Clonazepam should not consume alcohol since doing so can reduce the effectiveness of Apo Clonazepam and increase the risk of side effects.

People who have an addiction to alcohol or other drugs should not take clonazepam except in rare situations under medical supervision.

Breathing: Clonazepam can suppress breathing. This effect on breathing may be more pronounced for people with breathing problems, brain damage, or who are taking other medications that suppress breathing (e.g., Codeine, Morphine). If you have severe breathing problems, discuss the risks and benefits of taking Apo Clonazepam your doctor.

Coordination problems: If you have a medical condition that affects coordination (e.g., spinal or cerebellar ataxia, discuss with your doctor how Apo Clonazepam may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Clonazepam, and whether any special monitoring is needed.

Dependence and withdrawal: Physical dependence (a need to take regular doses to prevent physical symptoms) has been associated with benzodiazepines such as clonazepam. Severe withdrawal symptoms may occur if the dose is significantly reduced or suddenly stopped. These symptoms include seizures, irritability, nervousness, sleep problems, agitation, tremors, Diarrhea, abdominal cramps, vomiting, memory impairment, headache, muscle pain, extreme anxiety, tension, restlessness, and confusion. Reducing the dose gradually under medical supervision can help prevent or decrease these withdrawal symptoms. Do not suddenly stop taking Apo Clonazepam without talking to your doctor.

Depression: Clonazepam, like other benzodiazepines, has been known to cause mood swings and symptoms of depression. If you have depression or a history of depression, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Clonazepam, and whether any special monitoring is needed. If you experience symptoms of depression such as poor concentration, changes in weight, changes in sleep, decreased interest in activities, or notice them in a family member who is taking Apo Clonazepam contact your doctor as soon as possible.

Clonazepam is not recommended for use by people with depression or psychosis or who have attempted suicide.

Drowsiness/reduced alertness: Because clonazepam causes drowsiness and sedation, avoid activities requiring mental alertness, judgment, and physical coordination (such as driving or operating machinery) while taking it. This is particularly true when first taking the medication and until you have established how clonazepam affects you. Alcohol can increase the drowsiness effects and should be avoided.

Grapefruit juice: Avoid drinking grapefruit juice while you are taking Apo Clonazepam as it can increase the levels of clonazepam in your blood.

Kidney function: Decreased kidney function or Kidney Disease may cause Apo Clonazepam to build up in the body, causing side effects. If you have kidney disease or reduced kidney function, discuss with your doctor how Apo Clonazepam may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Clonazepam, and whether any special monitoring is needed.

Lactose intolerance: Lactose is one of the ingredients in this medication. If you have a hereditary condition that makes you intolerant to lactose, discuss other alternatives with your doctor.

Liver function: If you have liver disease or decreased liver function, discuss with your doctor how Apo Clonazepam may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Clonazepam, and whether any special monitoring is needed. People with severe liver problems should not take Apo Clonazepam.

Memory: Apo Clonazepam may impair recent memory. If you experience this while taking Apo Clonazepam, contact your doctor.

Porphyria: If you have porphyria, discuss with your doctor how Apo Clonazepam may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Clonazepam, and whether any special monitoring is needed.

Seizures: For some people taking Apo Clonazepam, seizures may worsen or a new type of seizure can occur. If you experience worsening seizures or the frequency of your seizures does not decrease while taking this medication, contact your doctor.

Pregnancy: Taking clonazepam during pregnancy can increase the risk of certain birth defects. Apo Clonazepam should only be used during pregnancy if the benefits outweigh the risks. If you become pregnant while taking Apo Clonazepam, contact your doctor immediately. Do not stop taking Apo Clonazepam suddenly, as this may result in withdrawal symptoms. Discuss the options with your doctor and follow their instructions closely.

Breast-feeding: Apo Clonazepam passes into breast milk. If you are a breast-feeding mother and are taking clonazepam, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: If long-term use of clonazepam is being considered for a child, discuss with your child's doctor the benefits and the risks of clonazepam use. Long-term use may have an effect on your child’s physical and mental development.

Seniors: Seniors may be at increased risk for the sedative and impaired coordination effects of Apo Clonazepam. This can increase the risk of falls and fractures. Seniors may require lower doses of Apo Clonazepam.

References

All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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Side effects of Klonopin (clonazepam)

Klonopin (clonazepam) are usually prescribed for the treatment of such conditions as panic disorder, anxiety and certain types of seizures. You can develop a physical dependence on Klonopin if you take the drug for two or more weeks. Therefore, this drug must be prescribed with caution and gradually withdrawn when treatment is no longer required.

If you were prescribed Klonopin, you should take the time to learn about the possible side effects, withdrawal and overdose symptoms. Rivotril is a Canadian trademark of the drug.

Benefit

Klonopin belongs to the class of drugs known as benzodiazepines. It is available in both pills and dissolve tablet form. The drug was approved by the Food and Drug Administration for the treatment of some types of seizure disorders in adults and children and panic disorders with or without agoraphobia (fear of open spaces).

Klonopin can also be used for the treatment of alcohol withdrawal, sleep problems caused by antipsychotics and anxiety associated with bipolar disorder or other mood disorders.

In combination with opioids or alcohol, benzodiazepines can cause serious side effects, including extreme sedation, labored breathing, coma and even death. To avoid serious complications, you must tell your doctor about all non-prescription, prescription, traditional, naturopathic, dietary or homeopathic medicines you are taking.

Side effects

Some side effects can develop during the first injection of Klonopin, many of which will disappear on their own as your body starts to adjust to the treatment.

According to the Department of Health and Human Services, you should call your doctor if any of these common side effects are serious or persistent:

  • Drowsiness
  • Vertigo
  • Instability
  • Coordination disorders
  • Thinking and memory problems
  • Hypersalivation
  • Muscle or joint pain
  • Frequent urination
  • Blurred vision
  • Changes in libido or sexual function

More rarely, Klonopin can cause chest congestion, runny nose, shortness of breath, heart palpitations, hair loss, hirsutism (excessive hair growth), skin rash, covered tongue, constipation, dry mouth, inflammation of guns, lymphadenopathy (swollen lymph nodes) and anemia.

If you experience these or any other unusual side effects, call your doctor immediately.

In rare cases, the side effects can develop quickly and become potentially life-threatening. Seek emergency medical attention if you experience any of the following symptoms:

  • Rash or hives
  • Swelling of the eyes, face, lips, tongue or throat
  • Difficulty swallowing
  • Shortness of breath and wheezing
  • Hoarseness
  • Disorientation
  • Fast or irregular heartbeat
  • Sickness or vomiting
  • Sense of impending doom

All these are the symptoms of severe allergic reaction of the whole body, known as anaphylaxis. If not treated, anaphylaxis can lead to respiratory or heart failure, seizures, coma and death.

Withdrawal syndrome

You should never stop taking Klonopin suddenly without the doctor’s permission if you have taken this drug for more than three months or use it to control seizures. If you need to stop the treatment, your doctor will gradually wean you from it.

Some of the most widespread withdrawal symptoms include:

  • Irritability
  • Nervousness
  • Sleep problems

These symptoms are relatively manageable. They will disappear after the reduction of the daily dose.

When to call your doctor?

Call your doctor immediately if you experience any of the following (more serious) withdrawal symptoms:

  • Stomach cramps
  • Tingling or burning sensation
  • Rapid heartbeat
  • Photosensitivity
  • Noise sensitivity 
  • Increased touch/pain sensitivity
  • Profuse sweating
  • Muscle spasms
  • Sickness or vomiting
  • Depression
  • Confusion
  • Paranoia or abnormal thoughts
  • Hallucinations

Symptoms of overdose

If you think that someone overdosed on Klonopin, contact the nearest emergency room. Symptoms of Klonopin overdose include:

  • Clammy skin
  • Extreme sedation
  • Movement disorder
  • Slowed reflexes
  • Difficulty breathing
  • Weak and fast pulse
  • Coma

The treatment can include gastric lavage (emptying of the stomach), intravenous fluid therapy, artificial ventilation, flumazenil to prevent sedation and levarterenol (norepinephrine) or auramine (metaraminol) for the treatment of dangerous drop in blood pressure.

 

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She was a little surprised at my arrival, but at the same time, she was glad. Well, come on, son, said my mother, her name, by the way, was Lyuba. I went in and told about my problems. Mom listened to me and offered to stay with her for a while (my father, it turned out, went on a business trip. For a week).



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